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Open Cancer Clinical Trials

The University of Chicago Medicine Comprehensive Cancer Center is leading the way in biomedical discoveries that will help physicians fight cancer more effectively. Our dedicated researchers and clinicians are conducting clinical trials in phases I, II, III and IV, leading to the development of new and better treatments. If you are a patient or a caregiver and would like to learn more our cancer clinical trials call toll-free 1-855-702-8222 (adult trials) or 1-773-702-6808 (pediatric trials) or email .

Prostate Cancer Clinical Trials
Interventional only

Phase II
Study No PI Title
IRB17-1767 Szmulewitz, Russell Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone Acetate and Apalutamide (ARN-509) for Rising PSA after Radical Prostatectomy with Adverse Features. Facilitating Optimal Radiation Management Using Leuprolide, Abiraterone Acetate, and Apalutamide (FORMULA-509 Trial) Details
IRB17-0963 Szmulewitz, Russell A Phase 1b/2 Study of the Oral CDK4/6 Inhibitor LEE011 (Ribociclib) in Combination with Docetaxel plus Prednisone in Metastatic Castration Resistant Prostate Cancer Details
IRB17-0784 Szmulewitz, Russell Overcoming drug resistance in metastatic castration-resistant prostate cancer with novel combination of TGF-ß receptor inhibitor LY2157299 and enzalutamide: a randomized multi-site phase II study Details
IRB17-0493 Szmulewitz, Russell A Randomized Phase II Trial of Abiraterone, Olaparib, or Abiraterone + Olaparib in Patients with Metastatic Castration-Resistant Prostate Cancer with DNA Repair Defects Details
IRB17-0044 Patnaik, Akash A Phase 3 Study of Androgen Annihilation in High-Risk Biochemically Relapsed Prostate Cancer Details
IRB16-1507 Patnaik, Akash TRITON2: A Multicenter, Open-label Phase 2 Study of Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer Associated with Homologous Recombination Deficiency Details
CIRB15-1357 Luke, Jason EAY131: Molecular Analysis for Therapy Choice (MATCH) Details
IRB14-1543 Liauw, Stanley Phase II Randomized Placebo-Controlled Double-Blind Study of Salvage Radiation Therapy (SRT) Plus Placebo Versus SRT Plus Enzalutamide in Men with High-Risk PSA-Recurrent Prostate Cancer after Radical Prostatectomy Details
IRB13-0979 Szmulewitz, Russell A Phase I/II Trial of Enzalutamide plus the Glucocorticoid Receptor Antagonist Mifepristone for Patients with Metastatic Castration Resistant Prostate Cancer (CRPC) Details
Phase I
Study No PI Title
IRB17-1395 Szmulewitz, Russell Phase IB Trial of Radium-223 and Niraparib in Patients with Castrate Resistant Prostate Cancer Details
IRB16-1743 Ratain, Mark An Open Label Phase I, First-In-Human Study of TRAIL Receptor Agonist ABBV-621 in Subjects with Previously-Treated Solid Tumors and Hematologic Malignancies Details
IRB16-0257 Luke, Jason A Two Part, Phase I, Multicenter, Open-Label Study of TRX518 in Adults with Advanced Solid Tumors Part A: A Dose-Escalation Study of Multi-dose TRX518 Monotherapy Part B: An Expansion Cohort of Multi-dose TRX518 Monotherapy at the Maximum Tolerated Dose Details
IRB13-0979 Szmulewitz, Russell A Phase I/II Trial of Enzalutamide plus the Glucocorticoid Receptor Antagonist Mifepristone for Patients with Metastatic Castration Resistant Prostate Cancer (CRPC) Details
Study No PI Title
IRB18-0531 Szmulewitz, Russell Shared Decision Making in Advanced Prostate Cancer
IRB16-1733 Szmulewitz, Russell Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) Details
IRB13-1295 Szmulewitz, Russell Prostate Cancer Sample Collection
IRB13-0756 Oto, Aytekin Quantitative DCEMRI of Prostate Cancer Correlation with Gold Standards
11-0061 Liauw, Stanley Evaluation of endorectal MRI for risk stratification, treatment planning, and workup after biochemical failure in patients with adenocarcinoma of the prostate
10-487-A O'Donnell, Peter The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing Details
14934A Liauw, Stanley Radiotherapy for Prostate Cancer: Dosimetric and Clinical Outcomes in the IMRT Era
12278A Steinberg, Gary Clinical Urology Research Screening Protocol

Although our objective is to provide on updated listings of clinical trials, please note that a listing here does not guarantee that a trial is open or available to any specific patient. Additional trials may be available that are not listed. Complete information is available only from a treating physician.

Are you part of the research staff and cannot see your study listed here? Please contact the cancer center IT Team .