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Open Cancer Clinical Trials

The University of Chicago Medicine Comprehensive Cancer Center is leading the way in biomedical discoveries that will help physicians fight cancer more effectively. Our dedicated researchers and clinicians are conducting clinical trials in phases I, II, III and IV, leading to the development of new and better treatments. If you are a patient or a caregiver and would like to learn more our cancer clinical trials call toll-free 1-855-702-8222 (adult trials) or 1-773-702-6808 (pediatric trials) or email .

Ovary/Fallopian Tube/Primary Peritoneal Cancer Clinical Trials
Interventional only

Phase III
Study No PI Title
IRB16-1770 Moroney, John GOG Partners 3015: A Phase III, Multicenter, Randomized, Placebo- Controlled Study of Atezolizumab Versus Placebo in Combination with Paclitaxel, Carboplatin, and Bevacizumab for Patients with Newly Diagnosed Stage III/IV Ovarian, Fallopian tube, or Primary Peritoneal Cancer Details
Phase II
Study No PI Title
IRB17-0627 Moroney, John A Phase II Open- Label Study of NUC-1031 in Patients with Platinum-Resistant Ovarian Cancer Details
IRB17-0114 Brooks, Rebecca A Phase II Randomized Study: Outcomes after Secondary Cytoreductive Surgery with or without Carboplatin Hyperthermic Intraperitoneal Chemotherapy (HIPEC) followed by Systemic Combination Chemotherapy for Recurrent Platinum- Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Details
IRB16-1602 Yamada, Diane Phase II Study of Four Dose Levels of Intraperitoneal NanoPac® Plus Six Cycles of IV Carboplatin and Paclitaxel in Patients with Platinum-Sensitive Recurrent Epithelial Ovarian Cancer Undergoing Second Cytoreductive Surgery Details
IRB16-1368 Fleming, Gini An Open Label Phase II Trial of Guadecitabine and Pembrolizumab in Platinum Resistant Recurrent Ovarian Cancer Details
CIRB15-1357 Sharma, Manish EAY131: Molecular Analysis for Therapy Choice (MATCH) Details
IRB13-1235 Yamada, Diane A Randomized Placebo Controlled Phase II Trial of Metformin in Conjunction with Chemotherapy Followed by Metformin Maintenance Therapy in Advanced Stage Ovarian, Fallopian Tube & Primary Peritoneal Cancer Details
10-726-A Moroney, John GOG 264: A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex Cord-Stromal Tumors of the Ovary Details
Phase I
Study No PI Title
IRB17-1396 Fleming, Gini An Open-Label, Phase 1 Study of SC-004 in Subjects with Advanced Solid Cancers Details
IRB16-1583 Fleming, Gini A Phase 1a/1b Dose Escalation and Expansion Study of Single-Agent SC-003 in Subjects with Platinum-Resistant/Refractory Ovarian Cancer (SCRX003-001) Details
IRB16-1743 Ratain, Mark An Open Label Phase I, First-In-Human Study of TRAIL Receptor Agonist ABBV-621 in Subjects with Previously-Treated Solid Tumors and Hematologic Malignancies Details
IRB16-0257 Luke, Jason A Two Part, Phase I, Multicenter, Open-Label Study of TRX518 in Adults with Advanced Solid Tumors Part A: A Dose-Escalation Study of Multi-dose TRX518 Monotherapy Part B: An Expansion Cohort of Multi-dose TRX518 Monotherapy at the Maximum Tolerated Dose Details
IRB15-1024 Luke, Jason A Platform Study Exploring the Safety, Tolerability, Effect on the Tumor Microenvironment, and Efficacy of INCB Combinations in Advanced Solid Tumors Details
IRB15-1130 Chmura, Steven Phase I study of PD1 blockade by pembrolizumab with stereotactic body radiotherapy in advanced solid tumors Details
Study No PI Title
IRB16-0606 Romero, Iris Stand Up To Cancer: WISP Trial (Women Choosing Surgical Prevention) Details

Although our objective is to provide on updated listings of clinical trials, please note that a listing here does not guarantee that a trial is open or available to any specific patient. Additional trials may be available that are not listed. Complete information is available only from a treating physician.

Are you part of the research staff and cannot see your study listed here? Please contact the cancer center IT Team .