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Clinical Trial Details

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Brief Title Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions
Official Title Randomized Placebo- Controlled Pilot Study of ZD6474 as a Chemopreventive Agent for Premalignant Lesions of the Head and Neck
Principal Investigator De Souza, Jonas
Brief Summary This randomized phase II trial studies how well vandetanib works in preventing head and neck cancer in patients with precancerous head and neck lesions. Chemoprevention is the use of certain drugs to keep cancer from forming. The use of vandetanib may keep cancer from forming in patients with premalignant lesions
Gender Both
Ages 18 Years
Enrollment 54
Accepts Healthy Volunteers No
Lead Sponsor University of ChicagoOther
Collaborator National Cancer Institute (NCI)NIH
Study Design Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
Study Phase Phase 2
Study Type Interventional
Contact Name Ezra E. Cohen
Contact Phone 1-855-702-8222 (adult trials) or 1-773-702-6808 (pediatric trials)
Condition Lip and Oral Cavity Squamous Cell Carcinoma
Detail for Health Professional (on
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